Make sure you're using a no-CD patch for the correct version of the game. If you can find the version of the game PM me and I'll get you a link to the patch. The site I use for no-CD's has questionable content, so we'll keep it off the boards.
EDIT: Next time please post gaming-related topics in the AMD Gaming forum:http://forums.amd.com/index.php?showforum=31
General discussion on IRC @ irc.protium.org / #forums.amd.irc ::: Folding for 34106
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