Yes, you may use another Radeon HD 7750/7770 in CrossFireX to transfer an application such as XSplit to another monitor on your primary Radeon HD 7750/7770. However, the monitor will need to be connected to your primary Radeon HD 7750/7770. If you disable CrossFireX, you may connect your additional monitor(s) to the secondary Radeon HD 7750/7770 and transfer the application.
However, please remember that Windows controls and determines whether or not you can dedicate all your system resources to support XSplit on one Radeon HD 7750/7770 and your game on the other Radeon HD 7750/7770.
AMD Customer Care
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