Just upgraded CCC from the box version that came with my 6850. The new CCC version is not detecting my 2nd graphics card, a 4650. Doesn't show up under CCC information\Hardware.

Current setup:

Windows 7

Radeon HD 6850 PCIe x8

Radeon HD 4650 PCIe x8

The card does appear in windows Device manager under "Display Adapter" as "ATI Radeon HD 4600 Series" , but properties window says "Windows has stopped this device because it has reported problems. (Code 43)".

I'm hoping that there's a good solution, other than revert back to old software.

Edit: downloaded from 11.8 page, appears I installed 12.10.

Ah, I see the issue. Goes along the same lines as the edit. 

4600 was listed under compatability for ccc 11.8. Now that I've viewed the release notes for 12.10, 4600 is no longer supported with the version I installed.