The last time I had an issue with my presets was around drivers 11.2 or somewhere in that area. With my eyefinity / Extended setup.
Basically all I did was uninstall the drivers. user a cleaner style program to remove all traces of said AMD software and reinstall them and they started working as intended.
Been working for a few years now for me without any issue. And I'm now running the latest drivers from AMD without a preset issue.
I5 3570K@4~5.0ghz: Gigabyte GA-Z77X-UD3H:Corsair Hydro H110 :16GB Corsair Vengeance DDR-3 1600: x2 XFX Radeon 7950 @ 1100/1575 : Corsair AX 860 PSU: x1 WD Black 1TB HDD's: 90GB Agility 3: 960GB SSD : Creative Labs X-FI:Corsair 500R Arctic White Edition:3 22inch Monitors Eyefinity @ 5294x 1050 : Alienware Tact-X Keyboard: Razer Naga :Corsair Vengence 1500 Headset: Corsair SP2500 Speakers