The original Titan pulled up to 260w, I find it hard to believe the following statement from nVidia:
And that performance is delivered in a card that is cool and quiet, rather than hot and loud. Low-profile components and ducted baseplate channels minimize turbulence and improves acoustic quality.
I think it'll have trouble staying under the 375w limit. And it'll still be beaten by a gamer class nVidia card with a fraction of the price tag.
ASUS Sabertooth 990FX/Gen3 R2, FX-8350 w/ Corsair H60, 8 GiB G.SKILL RipjawsX DDR3-2133, XFX HD 7970 Ghz, 512GB Vertex 4, 256GB Vector, 240GB Agility 3, Creative X-Fi Titanium w/ Creative Gigaworks S750, SeaSonic X750, HP ZR2440w, Win 7 Ultimate x64