I've updated Catalyst from 12.8 to 12.10 yesterday. Everything is OK except madVR (http://forum.doom9.org/showthread.php?t=146228).
I use MPC-HC (x86) + LAV Filter 0.52 (x86) with DXVA2 CB + madVR 0.84.3 to watch videos. With Catalyst from 12.8,I had no problem, the render queue was between 5 and 7 /8
However, with Catalyst from 12.10, there is many dropped/delayed frames. The render queue is now between 3 and 5 /8.
System : Windows 7 x64
GC : AMD Radeon HD 6800