So I have the following config

Windows 8 x64
Asus i7 3.4ghz
16 GB
3 x 240GB SSD in Raid 0
2 x Asus AMD 7850
4 x 23" Nec LCD's

The issue I am having is I have 3 displays hooked up to the first
video card and they work fine but the forth doesn't. It won't show any
video till I remove the AMD drivers and software sweet but as soon as
I reinstall it, it won't detect a forth screen. I have tried old, new
and beta drivers but no luck. And this is all a fresh install and the
LCD works fine and the cables are good.

Any ideas?

Deactivate Crossfire.

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Crosshair IV Formula, Phenom II x4 965 w/ Corsair H60, 8 GiB OCZ Platinum DDR3 1600, XFX HD 7970 Ghz, 512GB Vertex 4, 256GB Vector, 240GB Agility 3, Creative X-Fi Titanium w/ Creative Gigaworks S750, SeaSonic X750, HP ZR2440w, Win 7 Ultimate x64