kevinm10 - Thank you for referencing .net 4.5.
I've been fighting with this for a couple of months now. Chatted with support and they even setup and RMA for me.
I knew it had to be driver related, but I didn't even think of .net.
Now I'm running my 7770s in crossfire on Windows 7 with CCC version 13.4.
Again, THANK YOU!