Keeping in mind the hardware you'll need to support multiple graphic cards, what you are looking to do is possible. You cannot create a monster Eyefinity group that spans monitors connected to different graphics cards, however. I believe you are just looking to get 5+ extended desktops going, and that's okay.
Just follow the Eyefinity connectivity rules for each graphics card in use. Recall:
- A max of two legacy connections (DVI, VGA or HDMI) and the rest of the displays connected to the graphics card must be direct DP or using ActiveDP adapter.
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